Alternate pathways for folding in the flavodoxin fold family revealed by a nucleation-growth model.
نویسندگان
چکیده
A recent study of experimental results for flavodoxin-like folds suggests that proteins from this family may exhibit a similar, signature pattern of folding intermediates. We study the folding landscapes of three proteins from the flavodoxin family (CheY, apoflavodoxin, and cutinase) using a simple nucleation and growth model that accurately describes both experimental and simulation results for the transition state structure, and the structure of on-pathway and misfolded intermediates for CheY. Although the landscape features of these proteins agree in basic ways with the results of the study, the simulations exhibit a range of folding behaviours consistent with two alternate folding routes corresponding to nucleation and growth from either side of the central beta-strand.
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ورودعنوان ژورنال:
- Journal of molecular biology
دوره 358 3 شماره
صفحات -
تاریخ انتشار 2006